Paraspeckle condensation is controlled via TDP-43 polymerization and linked to neuroprotection

Nature·Mar 18

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Research suggests that paraspeckle condensation is controlled through TDP-43 polymerization and may be linked to neuroprotection. Studies are exploring the role of paraspeckles and TDP-43 in neurodegenerative diseases, including their interaction with other proteins and components. The formation and regulation of paraspeckles appear to be complex, involving various mechanisms and factors that are still being investigated.

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Linking TDP-43-regulated paraspeckle condensation to neuroprotection

Nature·Mar 30

Liquid-Liquid Phase Separation of TDP-43 and FUS in Physiology and Pathology of Neurodegenerative Diseases

Frontiers·Jun 26

Confined environments induce polarized paraspeckle condensates

Nature·Feb 3

C9-ALS/FTD-linked proline–arginine dipeptide repeat protein associates with paraspeckle components and increases paraspeckle formation

Nature·Oct 3

TDP-43 nuclear retention is antagonized by hypo-phosphorylation of its C-terminus in the cytoplasm

Nature·Jan 28

Emerging regulatory mechanisms and functions of biomolecular condensates: implications for therapeutic targets

Nature·Jan 6

Paraspeckles modulate the intranuclear distribution of paraspeckle-associated Ctn RNA

Nature·Sep 26

View original report at Nature ↗

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