Research on pancreatic organoids has shed light on the factors that influence the formation of lumens, with studies suggesting that pressure and cell growth play a role. The findings indicate that biomechanical forces, such as permeability-driven pressure and cell proliferation, can shape the development of pancreatic lumens. However, the specific mechanisms and factors involved in lumen morphogenesis are still being explored, with various studies examining the effects of hydrostatic pressure, stiffness, and bioelectric stimulation.