Primary biliary cholangitis is a condition that affects the liver and its management is crucial for maintaining quality of life. The incidence and prevalence of primary biliary cholangitis may be growing, and there are various approaches to its diagnosis and treatment, including the use of ursodeoxycholic acid. The condition can also overlap with other diseases, such as systemic sclerosis and autoimmune hepatitis, and its treatment options are expanding, although some questions remain.