Research is exploring the role of K63-linked ubiquitination in cancer, with studies investigating its involvement in various types of cancer, including esophageal squamous cell carcinoma, non-small cell lung cancer, gastric cancer, pancreatic cancer, and breast cancer. The process of K63-linked ubiquitination appears to be regulated by different factors, including enzymes and ligases, which can have either suppressive or promotional effects on cancer progression. The specific mechanisms and outcomes of K63-linked ubiquitination in cancer are still being investigated, with some studies identifying potential targets for anti-tumor therapy.