Rare variant analyses in 51,256 type 2 diabetes cases and 370,487 controls reveal the pathogenicity spectrum of monogenic diabetes genes

Nature·Oct 8

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Researchers have conducted a large-scale analysis of genetic variants in type 2 diabetes cases and controls, examining the role of monogenic diabetes genes. The study involved 51,256 type 2 diabetes cases and 370,487 controls, and its findings are being reported alongside other related research on the genetic architecture of type 2 diabetes. The various studies appear to be exploring different aspects of the genetic basis of type 2 diabetes, including rare variants, risk variants, and regulatory mechanisms.

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