Recurrent DNA break clusters drive replication-stress-induced copy number variants and genome diversification

Nature·Apr 20

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Research suggests that recurrent dna break clusters contribute to genome diversification and copy number variants due to replication stress. The relationship between replication stress and genome instability is being explored in various contexts, including cancer. Studies are investigating the underlying mechanisms and factors involved, such as defective replication fork protection and the role of specific genes and complexes.

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