Restoration of Oxacillin susceptibility in MRSA strains by NPPB

Nature·Jul 3

✦ NabkaNews BriefAuto-summarized from multiple outlets · verify with the source

Research has found that certain compounds can restore susceptibility to oxacillin in methicillin-resistant Staphylococcus aureus (MRSA) strains. Various studies have identified potential agents, including NPPB, berberine, naphthacemycins, and tripropeptin C, that may impact MRSA's resistance to beta-lactam antibiotics. The exact mechanisms and effects of these compounds are being explored in scientific research.

Full coverage

Role of SCCmec type in resistance to the synergistic activity of oxacillin and cefoxitin in MRSA | Scientific Reports

Nature·Jul 21

Berberine inhibits the tarO gene to impact MRSA cell wall synthesis

Nature·Feb 26

Naphthacemycins, novel circumventors of β-lactam resistance in MRSA, produced by Streptomyces sp. KB-3346-5. I. The taxonomy of the producing strain, and the fermentation, isolation and antibacterial activities

Nature·Mar 15

Natural lipopeptide antibiotic tripropeptin C revitalizes and synergistically potentiates the activity of beta-lactams against methicillin-resistant Staphylococcus aureus

Nature·Jan 14

Naphthacemycins, novel circumventors of β-lactam resistance in MRSA, produced by Streptomyces sp. KB-3346-5. II. Structure elucidation