Whole-genome sequencing in 333,100 individuals reveals rare non-coding single variant and aggregate associations with height
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Whole-genome sequencing has been used to study the genetic associations with height, with one study examining 333,100 individuals and another analyzing 672,976 individuals. The research has identified rare non-coding variants and aggregate associations with height, as well as convergence between rare and common genetic associations. The findings also suggest that integrating common and rare variants can improve polygenic risk prediction, with studies examining various populations, including japanese and korean groups.
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