Research has found that tolerogenic dendritic cells can be generated using minocycline and dexamethasone. Other studies are exploring various methods to induce these cells, including the use of endogenous biomolecules and acute phase proteins. The development of tolerogenic dendritic cells may have implications for immune system modulation and vaccine development, although some related research suggests that certain substances, such as prenatal betamethasone, can have interfering effects on immune system development.