Targeting ENO1 reprograms macrophage polarization to trigger antitumor immunity and improves the therapeutic effect of radiotherapy

Nature·Feb 2

✦ NabkaNews BriefAuto-summarized from multiple outlets · verify with the source

Research suggests that targeting a specific molecule, ENO1, can alter the behavior of macrophages, a type of immune cell, to fight cancer. This reprogramming may enhance the effectiveness of radiotherapy and potentially overcome resistance to antitumor drugs. The relationship between macrophages, tumor progression, and immune evasion is an area of ongoing study, with various therapeutic approaches being explored.

Full coverage

Lactate-mediated metabolic reprogramming of tumor-associated macrophages: implications for tumor progression and therapeutic potential

Frontiers·Apr 21

Targeting M2-like tumor-associated macrophages is a potential therapeutic approach to overcome antitumor drug resistance

Nature·Feb 10

Immune evasion in cancer: mechanisms and cutting-edge therapeutic approaches

Nature·Jul 31

Mechanism insights and therapeutic intervention of tumor metastasis: latest developments and perspectives

Nature·Aug 2

Tumour-vasculature development via endothelial-to-mesenchymal transition after radiotherapy controls CD44v6

Nature·Nov 30

View original report at Nature ↗