Research is focusing on the role of NRF2 in disease treatment, exploring its regulation through epigenetic and post-translational modifications. NRF2 is being studied in relation to various diseases, including cancer, diabetic kidney disease, and liver fibrosis, as well as its involvement in processes such as autophagy and apoptosis. The goal of this research appears to be the development of new therapeutic opportunities by targeting NRF2 and related mechanisms.