The status of the US President's Emergency Plan for AIDS Relief (PEPFAR) is uncertain amid a review of foreign aid by the Trump administration. There are reports of potential disruptions to PEPFAR programming, with some outlets suggesting that the program may be at risk, while others discuss the need for a transition plan. The implications of these developments for global health initiatives and beneficiaries are being analyzed, with some reports indicating that access to lifesaving HIV/AIDS medications may be affected.