The fatty acid synthase inhibitor orlistat reduces experimental metastases and angiogenesis in B16-F10 melanomas
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Research suggests that inhibiting fatty acid synthase, an enzyme involved in lipid metabolism, may have anti-cancer effects. Studies have implicated fatty acid synthase in various types of cancer, including melanoma, cervical cancer, prostate cancer, and colorectal cancer, and have explored its role in metastasis and tumor growth. The enzyme's inhibition, such as by the drug orlistat, may reduce metastases and angiogenesis in certain cancers, although the specific mechanisms and outcomes are still being investigated.
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