A therapeutic strategy targeting host lipolysis has been found to limit infection by SARS-CoV-2 and influenza A virus. Research into the relationship between lipid metabolism and viral infection has identified potential host targets, including FABP4, and pathways, such as the NF-κB signaling pathway, that may be involved in controlling infection. The exact mechanisms and effects of this strategy are being explored in various studies examining the intersection of viral infection, cellular processes, and immune response.