Researchers have made discoveries related to the organization of cells in tissues, including the identification of cellular neighborhoods and the characterization of tumor microenvironments. Various methods and tools, such as HRCHY-CytoCommunity, CellNiche, and TrimNN, have been developed to analyze spatial omics data and model spatially varying relationships in tissues. These studies have shed light on the complex organization of cells in tissues, including hierarchical tissue organization and spatial multicellular patterns.