Researchers are exploring various forms of non-apoptotic regulated cell death, including ferroptosis, pyroptosis, and necroptosis, for potential implications in treating malignant tumors. Studies are investigating the mechanisms and therapeutic perspectives of these cell death pathways in different types of cancer, such as melanoma and osteosarcoma. The findings may lead to novel therapeutic approaches for cancer treatment, including the use of nanomaterials and natural products to promote cell death in tumor microenvironments.