From TDP-43/RNA complex formation to disease-linked TDP-43 aggregation through a structural and cellular approach

Nature·Jan 21

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Research is being conducted on the protein TDP-43, exploring its role in cellular processes and its connection to disease. Studies are investigating how TDP-43 interacts with RNA and its involvement in neurodegenerative diseases, with some findings suggesting a link to neuroprotection and others to disease-causing mutations. The protein's behavior, including its aggregation and mislocalization, is being examined in various contexts, including intervertebral disc degeneration and neurodegenerative diseases such as ALS.

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TDP-43: unveiling the hidden key to cellular fate decisions

Springer Nature Link·Oct 22

Paraspeckle condensation is controlled via TDP-43 polymerization and linked to neuroprotection

Nature·Mar 18

TDP43 cytoplasmic mislocalization initiates mitochondrial dysfunction and intercellular senescence propagation in intervertebral disc degeneration

Nature·May 1

Disease causing mutants of TDP-43 nucleic acid binding domains are resistant to aggregation and have increased stability and half-life

PNAS·Mar 3

Liquid-Liquid Phase Separation of TDP-43 and FUS in Physiology and Pathology of Neurodegenerative Diseases

Frontiers·Jun 26

ALS-Linked Mutations Enlarge TDP-43-Enriched Neuronal RNA Granules in the Dendritic Arbor

Journal of Neuroscience·Mar 19

HSP70 chaperones RNA-free TDP-43 into anisotropic intranuclear liquid spherical shells

Science | AAAS·Dec 17

Autophagy and Its Impact on Neurodegenerative Diseases: New Roles for TDP-43 and C9orf72