Research on the klotho factor has yielded various findings, with one study suggesting that a domain of klotho enhances cognition in young and aging mice. However, other studies have explored different aspects of klotho, including its potential relationship to attention-deficit hyperactivity disorder and its effects on mineral metabolism and bone microstructure. The factor's impact on cognition has also been investigated in nonhuman primates, with some research indicating a positive effect in aged individuals.