Researchers are exploring the use of on-chip dielectrophoretic manipulation for single-cell research, with various studies examining its principles, applications, and prospects. The technology involves the use of optoelectronic tweezers and lab-on-chip microsystems to manipulate and analyze individual cells, including neurons and circulating tumor cells. Different approaches and techniques, such as dielectrophoretic trapping and electroporation, are being investigated for their potential in single-cell research.