A one-month spaceflight has been found to compromise the bone microstructure, tissue-level mechanical properties, osteocyte survival, and lacunae volume in mature mice skeletons. Research on the effects of spaceflight on bone health is ongoing, with studies examining various aspects such as fracture healing, bone strength, and potential treatments for spaceflight-induced bone loss. The impact of microgravity on bone structure and function is being investigated through various methods, including systematic reviews and experiments on rodents.