A large-scale whole-exome sequencing analysis has identified protein-coding variants associated with immune-mediated diseases in a large group of adults. The analysis is part of a broader series of studies using whole-exome and whole-genome sequencing to investigate various diseases and traits, including amyotrophic lateral sclerosis, Parkinson's disease, and metabolic health. The specific findings and scope of these studies vary, with some focusing on rare genetic variants and others examining larger populations.