Researchers are exploring the use of microbial biomanufacturing for space exploration, considering factors such as alternative feedstocks and the challenges of microgravity on microbial biosynthesis. Studies on the International Space Station and other research have identified both opportunities and obstacles for biomanufacturing in space, with potential applications including waste management and sustainable habitats. Various approaches, including the use of designer microbes and extremophiles, are being investigated to support space exploration efforts.