Research suggests that NLRC5 may play a role in the progression of endometrial carcinoma by regulating the NF-κB pathway-mediated mismatch repair gene deficiency. However, the specific mechanisms and pathways involved are not entirely clear, with some studies indicating potential involvement of the PI3K/AKT signaling pathway in cervical cancer. The relationship between NLRC5 and cancer progression is being explored in various contexts, including immune regulation and epigenetic control.