Research suggests that activating SIRT1 with neuroheal has a neuroprotective effect, while inhibiting SIRT2 with AK7 is detrimental for disconnected motoneurons. The role of sirtuins, including SIRT1 and SIRT2, in the central nervous system is being studied in the context of neurological disorders. Neuroheal has also been found to promote regeneration and reduce muscle atrophy in a pre-clinical model of nerve damage.