Research is being conducted on the role of sirtuin deacetylases, including SIRT1 and SIRT2, in neurodegenerative diseases. The activity of these enzymes may have varying effects, with some studies suggesting that activating or inhibiting them could be either beneficial or detrimental in different contexts. The relationship between sirtuins and neurodegenerative diseases, such as Parkinson's disease, is being explored, with some studies also investigating the potential therapeutic potential of related factors.