Research is being conducted on the role of sirtuin deacetylases in neurodegenerative diseases associated with aging. Studies are investigating the potential therapeutic targets of sirtuins, including their activity and regulation, in relation to diseases such as Alzheimer's. The specific functions and effects of different sirtuins, including SIRT1, SIRT2, and SIRT6, are being explored in various contexts, including neuroinflammation, epigenetic modification, and autophagic regulation.