Purine metabolism rewiring improves glioblastoma susceptibility to temozolomide treatment | Cell Death & Disease

Nature·Apr 24

✦ NabkaNews BriefAuto-summarized from multiple outlets · verify with the source

Research suggests that altering purine metabolism may improve the effectiveness of temozolomide treatment for glioblastoma. Studies have identified various mechanisms by which purine metabolism contributes to therapy resistance in glioblastoma, including dna repair and cell cycle progression. The findings may point to new strategies for overcoming resistance to temozolomide treatment in glioblastoma patients.

Full coverage

Targeting metabolic reprogramming in glioblastoma as a new strategy to overcome therapy resistance

Frontiers·Feb 25

Purine metabolism regulates DNA repair and therapy resistance in glioblastoma

Nature·Jul 30

One-carbon-mediated purine synthesis underlies temozolomide resistance in glioblastoma

Nature·Oct 25

Carmofur prevents cell cycle progression by reducing E2F8 transcription in temozolomide-resistant glioblastoma cells

Nature·Dec 12

Tumour exosomes from cells harbouring PTPRZ1–MET fusion contribute to a malignant phenotype and temozolomide chemoresistance in glioblastoma

Nature·May 15

View original report at Nature ↗