Rare genetic diseases associated with G-quadruplex-induced replication stress

Nature·Apr 13

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Research has found a link between rare genetic diseases and G-quadruplex-induced replication stress. Studies have investigated the role of various proteins and mechanisms, such as G-quadruplex-binding proteins and DNA helicases, in responding to this stress and maintaining DNA stability. The dynamics of G-quadruplex DNA structures and their impact on replication and transcription are being explored in different contexts, including liver regeneration and telomere replication.

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View original report at Nature ↗

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