Single-molecule imaging reveals replication fork coupled formation of G-quadruplex structures hinders local replication stress signaling

Nature·May 5

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Research using single-molecule imaging has shed light on the formation of G-quadruplex structures during DNA replication. This process appears to be linked to replication stress and may be involved in certain genetic diseases. The exact mechanisms and relationships between G-quadruplex structures, replication stress, and DNA repair are being explored through various studies, with some focusing on the roles of specific proteins and helicases.

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View original report at Nature ↗

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