research on the cell-cell fusogen EFF-1 has shed light on its structure, being monomeric and upright on the membrane. studies have also explored the role of various factors, including RAB-5 disruption and metalloprotease ADM-4/ADAM17, in promoting axonal repair and fusion. the relationship between EFF-1 and other proteins, such as HAP2 and AFF-1, is also being investigated in the context of cell fusion and regeneration.