Design, synthesis, molecular docking and cytotoxic evaluation of novel pyrimidine-based sulfonamide derivatives as potent anticancer agents: SAR insights and biological profiling

Nature·Mar 24

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Researchers have been designing, synthesizing, and evaluating various novel compounds, including pyrimidine-based sulfonamide derivatives, as potential anticancer agents. The compounds have undergone molecular docking, cytotoxic evaluation, and other studies to assess their therapeutic potential. The specific details and outcomes of these studies vary across different reports, which cover a range of compounds and methodologies.

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Design, synthesis, and biological evaluation of novel 6-(4-aminopiperidin-1-yl)-substituted benzyl-3-methylpyrimidine-2,4(1H,3H)-dione derivatives as potential anticancer agents targeting thymidylate synthase

Nature·Nov 20

Green synthesis, one-pot reaction, biological evaluation, and molecular docking studies of new pyrazolo[3,4-d]tetrazolo[1,5-a]pyrimidine derivatives

Nature·Jun 23

The anticancer therapeutic potential of pyrimidine–sulfonamide hybrids: Future Medicinal Chemistry: Vol 16, No 9

Taylor & Francis Online·Dec 7

Design, synthesis, characterization, pharmacological evaluation and in silico ADMET and molecular docking and dynamics simulations of a novel series of N-substituted pyrazole from chalcone derivatives | Scientific Reports

Nature·Mar 1

Solid-phase synthesis and cytotoxic evaluation of novel pyridinium bromides

Nature·Mar 24

Design, click-based synthesis, molecular docking, molecular dynamics and anticancer activity of new isoindoline-1,3-dione- triazole-glycopyranosyl hybrids

Nature·May 26

Design synthesis, characterization, molecular docking and antimicrobial evaluation of novel heterocycles with acrylonitrile and anthracene moieties | Scientific Reports

Nature·Jun 3

Synthesis, comprehensive in silico studies, and cytotoxicity evaluation of novel quinazolinone derivatives as potential anticancer agents | Scientific Reports

Nature·Jul 3

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