Emerging roles of SIRT1 activator, SRT2104, in disease treatment

Nature·Mar 6

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Research is exploring the potential therapeutic roles of SRT2104, a SIRT1 activator, in treating various diseases. Studies suggest that SIRT1 activation may have benefits in areas such as auditory cell health, cerebral ischemic stroke, metabolic and cardiovascular diseases, and neurodegenerative diseases. The mechanisms underlying SIRT1's effects, including its regulation of autophagy and cellular signaling, are also being investigated.

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SIRT1 activation by SRT2104 enhances mitophagy and reduces senescence in auditory cells

Nature·Jan 27

New insights into Sirt1: potential therapeutic targets for the treatment of cerebral ischemic stroke

Frontiers·Aug 8

Sirtuins and NAD+ in the Development and Treatment of Metabolic and Cardiovascular Diseases | Circulation Research

American Heart Association Journals·Sep 13

SIRT1 and SIRT2 Activity Control in Neurodegenerative Diseases

Frontiers·Feb 5

SRT2104 enhances dendritic outgrowth and spine formation through Sirtuin 1-mediated mTORC1 signaling

Nature·Jul 1

Mechanisms and disease implications of sirtuin-mediated autophagic regulation

Nature·Sep 6

Resveratrol serves as a protein-substrate interaction stabilizer in human SIRT1 activation

Nature·Nov 30

SIRT1 ubiquitination is regulated by opposing activities of APC/C-Cdh1 and AROS during stress-induced premature senescence

Nature·Jun 1

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