Research on medulloblastoma, a type of brain tumor, has led to the identification of various factors that contribute to its development and progression. The role of MYC and MYCN in driving medulloblastoma has been explored, with studies suggesting potential therapeutic vulnerabilities and opportunities for targeted treatment. The use of CRISPR technology and other approaches has enabled the creation of novel models and the investigation of transcriptional networks in medulloblastoma, advancing the understanding of this disease.