Javed Anees · CC0India’s first dengue vaccine arrives with a crucial safety caveat
India's first dengue vaccine, Qdenga, has become available but with a significant safety caveat. In children who have never had a dengue infection, the vaccine can simulate a primary infection, conferring protection against DENV-1 and DENV-2 but not DENV-3, and potentially enhancing later DENV-3 disease. This makes prior-infection status central to who benefits.
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India's first dengue vaccine and its serotype-specific caveat are topical science-and-technology material.
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- Qdenga is India's first dengue vaccine.
- In previously uninfected children it protects against DENV-1 and DENV-2 but not DENV-3.
- The vaccine may enhance dengue in children who have not had a prior infection.
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